Disintegrant definition: A disintegrant is an agent, used in the preparation of tablets, which causes them to... | Meaning, pronunciation, translations and examples
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1. The extracted case was so old it just disintegrated when a worker picked it up. ", 。. ". 2. Results show that hydrogen-rich …
The present study comprises the various kinds of superdisintegrants which are being used in the formulation to provide the safer, effective drug delivery with patient's compliance. An oral solid dosage form should ideally disperse into the primary particles from which it was prepared. Tablets and capsules which need rapid disintegration, the inclusion of the right …
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disintegrate in British English. (dɪsˈɪntɪˌɡreɪt ) . 1. to break or be broken into fragments or constituent parts; shatter. 2. to lose or cause to lose cohesion or unity. 3. (intransitive) …
Disintegrants are the most vital excipient in pharmaceutical formulations. They also known as disintegrating agents or disintegrators. The process by which a solid oral dosages form such as tablet breaks …
The most accepted mechanism for tablet disintegration is by disintegrant swelling.8, 12 Swelling is associated with dimensional amplification where particles enlarge omni-directionally to push apart the adjoining components, thereby initiating the break-up of the tablet matrix (). 13 Most popular disintegrants swell to some extent and swelling …
Translation for 'disintegrate' in the free English-Chinese dictionary and many other Chinese translations.
An Overview of Disintegrants. The ability of the active ingredient in a drug to be absorbed by the body depends on its bioavailability. This, in turn, is a function of the solubility of the active ingredient in the gastrointestinal fluids as the drug passes through the intestines. The ability to dissolve depends on the physical form and ...
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It was concluded that the batch F3 formulated by using combination of crosspovidone super-disintegrant shows excellent disintegration time 142±1.50 seconds, enhance dissolution rate 95.23±2.5% ...
Methods: Mouth Dissolving Tablets (MDTs) of Tofacitinib Citrate were developed by full factorial design at 32levelsand prepared by direct compression method using super integrants like sodium ...
disintegrant: [ dis-in´tĕ-grant ] an agent used in pharmaceutical preparation of tablets, which causes them to disintegrate and release their medicinal substances on contact with moisture.
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Disintegrant, normally used in 2% concentration in tablets made by direct compression and 3% by wet granulation. White or grayish-white powder, practically insoluble in anhydrous ethanol. Hygroscopic. Insoluble in water but rapidly swells in it to four to eight times the original volume. Density in bulk 0.53 g/ml. pH 5–7 in an aqueous slurry.
The swelling of disintegrant particles in different media was determined by laser diffraction particle size analyser by Zhao and Augsburger. Anionic disintegrants croscarmellose sodium and sodium …
. ( Pharmaceutical: Excipients) A disintegrant is an agent, used in the preparation of tablets, which causes them to disintegrate and release their medicinal substances on …
The detrimental effect of high relative humidity on XPVP is attributed to the high absorption of moisture which acts as a plasticiser for the disintegrant in the dry state, causing, in turn, a premature release of the energy stored within the compressed disintegrant particles and an increase in tablet thickness (i.e. shape-recovery in the dry ...